What does domestic (yerli) probiotic mean?

A probiotic microorganism whose strain was isolated and identified in Türkiye and/or which is manufactured at a facility in Türkiye. In its strongest sense both the strain and the production are domestic.

Is a domestic probiotic better than an imported one?

Quality comes from strain-level identification, a guaranteed viable count at end of shelf life and documented production, not from where the strain comes from. The advantage of domestic production is that these criteria can be verified directly with the manufacturer and supply is predictable.

Is there a manufacturer of probiotic raw materials in Türkiye?

Yes. Shymeriae Biotechnology manufactures probiotic, postbiotic and parabiotic raw materials to GMP standards in Ataşehir, Istanbul, and its culture collection is published on the official culture collection list.

Domestic Probiotics: Strains Developed and Manufactured in Türkiye

A domestic ("yerli") probiotic is a probiotic microorganism whose strain was isolated and identified in Türkiye and which is manufactured at a facility in Türkiye. Shymeriae Biotechnology develops and manufactures probiotic, postbiotic and parabiotic raw materials at its facility in Ataşehir, Istanbul, and its culture collection is published on the official culture collection list.

Last updated: 10 November 2026

What is a domestic probiotic?

The term can mean two things: that the strain was isolated in Türkiye, and that production takes place in Türkiye. In its strongest sense it covers both: the strain is isolated from a natural source in Türkiye, identified by molecular methods, deposited in a culture collection, and every step from fermentation to freeze-drying is carried out locally.

Encapsulating or packaging an imported ready-made culture in Türkiye does not by itself make the raw material domestic. What matters is the origin of the strain and where the raw material is produced, both verifiable through the strain code and the certificate of analysis (CoA).

Domestic vs imported probiotic raw materials

For a formulator the difference comes down to four points:

Strain origin: domestic strains are isolated from natural sources in Türkiye; imported materials rely on a collection held abroad.
Supply: imports depend on exchange rates, freight, customs and cold-chain transit time. Domestic production means a short supply chain and more predictable lead times and prices.
Technical support: strain selection, dosage and formulation compatibility can be worked out directly with the manufacturer.
Traceability: isolation source, collection record and batch CoA come from a single manufacturer.

Domestic probiotic raw materials at Shymeriae

Shymeriae Biotechnology was founded in Istanbul in May 2025. It produces probiotic, postbiotic and parabiotic raw materials to GMP standards at its R&D and production facility in Ataşehir and holds ISO 22716 (GMP), ISO 9001, ISO 22000 and ISO 10002 certificates.

Its culture collection is published on the official culture collection list, and its R&D project on using local microbial strains in traditional yogurt production is supported by KOSGEB. Every strain in the catalog is published with its code, product form, biosafety level and literature record.

Lyophilised live cultures (probiotic)
Postbiotic lysates
Pasteurised or inactivated cells (parabiotic)

Frequently asked questions

What does domestic (yerli) probiotic mean?: A probiotic microorganism whose strain was isolated and identified in Türkiye and/or which is manufactured at a facility in Türkiye. In its strongest sense both the strain and the production are domestic.
Is a domestic probiotic better than an imported one?: Quality comes from strain-level identification, a guaranteed viable count at end of shelf life and documented production, not from where the strain comes from. The advantage of domestic production is that these criteria can be verified directly with the manufacturer and supply is predictable.
Is there a manufacturer of probiotic raw materials in Türkiye?: Yes. Shymeriae Biotechnology manufactures probiotic, postbiotic and parabiotic raw materials to GMP standards in Ataşehir, Istanbul, and its culture collection is published on the official culture collection list.

Request a quote for domestic probiotic raw materials

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